Management of mould pneumonia in resource-limited settings in Asia: A Delphi-based consensus statement by the Asia Fungal Working Group.
Journal
Medical mycology
Journal Volume
63
Journal Issue
12
ISSN
1460-2709
Date Issued
2025-12-01
Author(s)
Chayakulkeeree, Methee
Tan, Ban Hock
Patel, Atul
Li, Ruoyu
Chindamporn, Ariya
Chua, Mitzi
Jabeen, Kauser
Lan, Nguyen Phu Huong
Low, Lee Lee
Sun, Pei-Lun
Wahyuningsih, Retno
Zhu, Li-Ping
Chakrabarti, Arunaloke
Abstract
Mould pneumonia can be life-threatening, and its incidence is increasing in Asia. Due to significant variability in diagnostic setups and the availability of antifungal agents, especially in resource-limited settings, the current treatment practices and recommendations for local clinicians are poorly described. This study aimed to develop a consensus statement on the clinical management of mould pneumonia in Asia, particularly within resource-limited settings. Clinicians and infectious disease experts from the Asia Fungal Working Group answered questions about the regional epidemiology as well as diagnostic and resource-limited treatment approaches of mould pneumonia. Guided by a literature review, 22 initial questions were generated and voted upon anonymously using a Delphi-based methodology with predefined consensus criteria. The study comprised two rounds: one to generate summary statements based on the panelists' questionnaire responses, and the other to review, confirm and rate the level of agreement of the consensus statements using a five-point Likert scale. The panelists generated 21 summary statements on the epidemiology (5), diagnosis (8), and treatment (8) of mould pneumonia, 20 of which achieved ≥ 70% consensus. Through a consensus-building exercise, clinical experts from Asia developed a set of 21 consensus statements for the diagnosis and management of mould pneumonia in resource-limited settings. © The Author(s) 2025. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.
Medical experts developed 21 practical guidelines for diagnosing and treating mould-associated lung infections in hospitals with limited resources. The recommendations help physicians choose appropriate tests, medications, and management approaches when standard options are not available.
Subjects
antifungal agents
aspergillosis
mucormycosis
pneumonia
respiratory tract infections
Type
journal article