CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
Journal
Scientific Reports
Journal Volume
10
Journal Issue
1
Pages
21367
Date Issued
2020
Author(s)
Wang P.-H.
Lee S.S.-J.
Wei Y.-F.
Abstract
A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT0 results and conducted two rounds of follow-up paired QFT-GIT1&2 and QFT-Plus1&2 tests at an interval of 6?months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT0 results were enrolled. The baseline QFT-GIT0 response was higher in the 1st QFT-Plus1(+) group than in the QFT-Plus1(?) group, but insignificantly different between the 1st QFT-GIT1(+) and QFT-GIT1(?) groups. The two assays had good correlation when concurrently tested. Fifty-three subjects completed a second round of the QFT-GIT2 and QFT-Plus2. Persistent positivity was higher with the QFT-Plus2 (81.8%) than with the QFT-GIT2 (58.8%, p = 0.040). The QFT-GIT1 and QFT-Plus1 CD4 responses were higher in patients with persistent positivity than in those with negative reversion, whereas the difference of the QFT-Plus TB1 and TB2 data, representative of the CD8 response, were similar between positive persistence and negative reversion. In conclusion, the QFT-Plus provides more reliable positive consistency than does the QFT-GIT. The CD4 interferon-γ response might play a role in maintaining positivity of LTBI. ? 2020, The Author(s).
SDGs
Other Subjects
biological marker; adult; aged; blood; CD8+ T lymphocyte; female; health care delivery; hemodialysis; human; immunology; interferon gamma release assay; latent tuberculosis; male; metabolism; middle aged; risk factor; Adult; Aged; Biomarkers; CD8-Positive T-Lymphocytes; Delivery of Health Care; Female; Humans; Interferon-gamma Release Tests; Latent Tuberculosis; Male; Middle Aged; Renal Dialysis; Risk Factors
Publisher
Nature Research
Type
journal article