Radiation-Induced Malignant Fibrous Histiocytoma in Patients With Nasopharyngeal Carcinoma
Journal
Archives of Otolaryngology�XHead and Neck Surgery
Journal Volume
122
Journal Issue
5
Pages
535-538
Date Issued
1996
Author(s)
Abstract
OBJECTIVE: To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma. DESIGN: Cohort. SETTING: Tertiary care hospital. PATIENTS: Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity. MAIN OUTCOME MEASUREMENT: Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. RESULTS: The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38%. The 15-year cumulative incidence was 2.2%. Most tumors occurred in the maxillary sinus and were characterized by spindle-shaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 20 and 32 months, respectively. CONCLUSIONS: Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.
Other Subjects
adult; aged; article; cancer recurrence; cancer survival; clinical article; female; human; incidence; male; malignant fibrous histiocytoma; maxilla sinus cancer; nasopharynx carcinoma; nose cavity cancer; prevalence; radiation injury; Adolescent; Adult; Aged; Child; Cohort Studies; Female; Histiocytoma, Benign Fibrous; Humans; Male; Maxillary Sinus; Maxillary Sinus Neoplasms; Middle Aged; Nasal Cavity; Nasopharyngeal Neoplasms; Nasopharynx; Neoplasms, Radiation-Induced; Radiotherapy
Type
journal article