Increased HIF-1α expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus
Journal
Journal of the Formosan Medical Association
Journal Volume
121
Journal Issue
12
Pages
2446 - 2456
Date Issued
2022-12
Author(s)
Abstract
Recent emerging evidence indicates that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE). This study was undertaken to investigate the expression of HIF-1α, a regulator of metabolic reprogramming, in T cells from SLE.
Subjects
CD4 T cells; HIF-1α; Metabolic reprogramming; SLE; Th17
Publisher
Elsevier B.V.
Type
journal article