Cortisol-producing adenoma-related somatic mutations in unilateral primary aldosteronism with concurrent autonomous cortisol secretion: their prevalence and clinical characteristics
Journal
European journal of endocrinology
Journal Volume
187
Journal Issue
4
Date Issued
2022-10-01
Author(s)
Peng, Kang-Yung
PO-CHIH LIN
Chen, Ting-Chu
Chueh, Jeff S
Abstract
Concurrent autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) is being reported more frequently. Several somatic mutations including PRKACA, GNAS, and CTNNB1 were identified in cortisol-producing adenomas (CPAs). The presence of these mutations in unilateral PA (uPA) patients concurrent with ACS (uPA/ACS) is not well known. This study aimed to investigate the prevalence of these mutations and their clinical vs pathological characteristics in uPA/ACS.
SDGs
Type
journal article