病理評估以lovastatin治療帶有人類未分化癌之裸鼠的癌細胞分化變化
Date Issued
2005
Date
2005
Author(s)
張天鈞
DOI
932314B002176
Abstract
Lovastatin and other HMG-CoA reductase inhibitors have been widely used to
reduce cardiovascular morbidity and mortality in many clinical studies, and they also
have effects unrelated to lipid reduction. In cellular levels, we showed that treatment of
human anaplastic thyroid cancer cells with lovastatin can induce cellular differentiation
in a lower dose (25 µM) and cellular apoptosis in a higher dose (50 µM) (10). Later, we
have revealed that lovastatin could inhibit cellular proliferation and induce apoptosis in
anaplastic thyroid cancer cell lines; meanwhile, we further showed that lovastatin
suppressed epidermal growth factor-induced cellular invasiveness via reduction of
geranylgeranylation of Rho/ROCK and FAK/paxillin signaling. The aim of the present
study was to observe the effect of lovastatin in nude mice with anaplastic thyroid cancer.
The nude mice were divided into 4 groups and observed for 30 days: A －negative
control group (n=10), injection of PBS only without treatment of lovastatin; B －
positive control group (n=10), injection of PBS loaded with ARO cells without
treatment of lovastatin; C －low dose treatment group (n=10), injection of PBS loaded
with ARO cells with treatment of lovastatin (1mg/kg); D －middle dose treatment
group (n=10), injection of PBS loaded with ARO cells with treatment of lovastatin
(5mg/kg); E －high dose treatment group (n=10), injection of PBS loaded with ARO
cells with treatment of lovastatin (10mg/kg). In group C, tumor growth seemed to be
more rapid than that of positive control group, but tumor growth in group D was
suppressed since Day 27. Prominent inhibition of tumor growth was shown in group E,
and tumor growth volume was significantly reduced in group E in comparison with
group B (P < 0.01). In conclusion, lovastatin can inhibit the anaplastic thyroid cancer
growth in nude mice in high dose. Further human clinical trial may be warranted.
Subjects
anaplastic thyroid cancer
nude mice
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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