Effect of heterogeneous dependence between two tests on estimation of diagnostic accuracy for semi-latent screening data
Date Issued
2009
Date
2009
Author(s)
Ho, Ching-Hsun
Abstract
When diagnosing a disease in a screening program, two diagnostic tests may be applied simultaneously. To confirm the accuracy of the two tests, a third gold standard test will usually be also used. However, due to realistic reasons, the confirmatory procedure is limited to individuals with positive results. Previous approaches assumed independence or homogeneous dependence of the two tests and used maximum likelihood or capture-recapture method to estimate the accuracy for each test. However, there are controversies about the dependence assumptions. Therefore, in this thesis we adopted two dependent models for discussing the influence of heterogeneous dependence on diagnostic accuracy. The results indicate that the direction of dependence will not affect accuracy estimates, but the strength will.
Subjects
accuracy
dependence
diagnostic test
Type
thesis
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