Allele Distribution at the Fmr1 Locus in the General Chinese Population
Resource
CLINICAL GENETICS v.55 n.5 pp.352-355
Journal
CLINICAL GENETICS
Journal Volume
v.55
Journal Issue
n.5
Pages
352-355
Date Issued
1999
Date
1999
Author(s)
Chiang, Shu-Chuan
Lee, Yu-May
Wang, Tso-Ren
Hwu, Wuh-Liang
Abstract
Fragile X syndrome is an important disease of hereditary mental retardation. Its prevalence in the Chinese population is not clear. We amplified FMR1 CGG repeats from male newborns' blood spots. Approximately 45% of the males had 28 CGG repeats and another 19% had 29 repeats. Besides this major peak, there was a second peak at 34 and 35 repeats. From the 1000 males studied, 3 were found to have repeat numbers in the high borderline range (each with 50, 52 and 53 repeats). This result provides a low but significant risk of fragile X syndrome in the Chinese population.
Subjects
CGG repeat
Chinese
FMR1
fragile X syndrome
FRAGILE-X-SYNDROME
CGG REPEAT
Type
journal article