Soluble adhesion molecules and cytokines in tumor-associated tissue eosinophilia of nasopharyngeal carcinoma
Journal
Acta Oto-Laryngologica
Journal Volume
121
Journal Issue
4
Pages
534-538
Date Issued
2001
Author(s)
Abstract
The phenomenon of tumor-associated tissue eosinophilia (TATE) is seen in some cases of nasopharyngeal carcinoma (NPC) and is characterized by the eosinophils breaking through the vascular wall and pervading the tumor stroma. The margination and trans-endothelial migration of eosinophils in a typical inflammatory reaction depend on the activating effects of certain cytokines and the expression of adhesion molecules on the eosinophils and endothelial cells. In order to investigate whether the adhesion molecules and activating cytokines play a role in eosinophil tumor infiltration, we measured the serum levels of 3 adhesion molecules, intercellular adhesion molecule-1, E-selectin and vascular cell adhesion molecule-1, and 2 cytokines, IL-3 and IL-5, in 60 NPC patients and 40 normal healthy subjects. We found that the NPC patients had higher serum levels of all three soluble adhesion molecules than the normal subjects but the levels of adhesion molecules failed to correlate with the TATE phenomenon. The levels of IL-3 and IL-5 appeared not to differ between the NPC and control groups. We postulate that the three soluble adhesion molecules do not play a major role in TATE and that their elevation in serum may be due to local and/or systemic immune responses.
SDGs
Other Subjects
cell adhesion molecule; cytokine; endothelial leukocyte adhesion molecule 1; intercellular adhesion molecule 1; interleukin 3; interleukin 5; vascular cell adhesion molecule 1; adult; article; cell migration; controlled study; cytokine production; eosinophilia; female; human; human cell; human tissue; immune response; immunoassay; inflammation; major clinical study; male; nasopharynx carcinoma; priority journal
Type
journal article