Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study
Journal
Reproductive biology and endocrinology : RB&E
Journal Volume
18
Journal Issue
1
Date Issued
2020-07-13
Author(s)
Abstract
Patients with polycystic ovarian syndrome (PCOS) are associated with known alterations in mitochondria DNA copy number (mtDNA-CN). The aim of this study is to study the change in mtDNA-CN in patients with PCOS who were treated with metformin.
Subjects
8-Hydroxy-2′-Deoxyguanosine; DNA mitochondrial; Female; Humans; Metformin; Polycystic ovary syndrome; Testosterone
SDGs
Other Subjects
8 hydroxydeoxyguanosine; liver enzyme; metformin; mitochondrial DNA; testosterone; antidiabetic agent; metformin; mitochondrial DNA; adult; Article; blood pressure; clinical trial; cohort analysis; copy number variation; disorders of mitochondrial functions; female; free androgen index; human; longitudinal study; major clinical study; metabolic parameters; ovary polycystic disease; prospective study; testosterone blood level; adolescent; body mass; drug effect; genetics; insulin resistance; ovary polycystic disease; pathology; physiology; young adult; Adolescent; Adult; Body Mass Index; DNA Copy Number Variations; DNA, Mitochondrial; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Longitudinal Studies; Metformin; Polycystic Ovary Syndrome; Young Adult
Publisher
BMC
Type
journal article