Impact of alfuzosin on sexual function in Taiwanese men with benign prostatic hyperplasia
Journal
Kaohsiung Journal of Medical Sciences
Journal Volume
28
Journal Issue
8
Pages
429-434
Date Issued
2012
Author(s)
Abstract
To assess the effect of alfuzosin (XATRAL) 10 mg once daily on sexual function in men with moderate to severe lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), patients with suggestive symptomatic BPH, an International Prostate Symptom Score (IPSS) >8 (range of scores, 0-35), and sexual attempts at least once per month were enrolled. All patients received alfuzosin 10 mg once daily for 24 weeks and were asked to complete the IPSS test and Male Sexual Health Questionnaire at weeks 0 (baseline), 1, 4, 12, and 24. Other assessments included the International Index of Erectile Function - five-item version (range of scores: 5-25), as well as onset of action and peak urinary flow rate (Qmax). From September 2006 to May 2008, 279 patients were enrolled from nine centers in Taiwan. At 24 weeks, alfuzosin effectively improved LUTS and quality of life, as demonstrated by a reduction in the IPSS total score (17.3 vs. 9.9, p < 0.001) and the IPSS bother score (3.8 vs. 2.5, p < 0.001). The majority (85%) of patients perceived an improvement of urinary symptoms within 1 month of administration. In patients with an International Index of Erectile Function - five-item version score of ?16, alfuzosin significantly improved erectile disorder and satisfaction subscores at each time point (p ? 0.02). Prolonged-release alfuzosin effectively improved LUTS, quality of life, erectile function, and sexual satisfaction in men with BPH and mild to severe erectile dysfunction. Alfuzosin is an effective treatment option for the management of patients with BPH/LUTS and concomitant sexual dysfunction. ? 2012, Elsevier Taiwan LLC. All rights reserved.
Subjects
Alfuzosin; Benign prostatic hyperplasia; Lower urinary tract symptoms; Sexual dysfunction
SDGs
Other Subjects
alfuzosin; alpha adrenergic receptor blocking agent; phosphodiesterase V inhibitor; tadalafil; adult; article; clinical assessment; controlled study; dizziness; drug withdrawal; erectile dysfunction; heart palpitation; human; human tissue; hypertension; International Index of Erectile Function; International Prostate Symptom Score; lower urinary tract symptom; male; multicenter study; prostate hypertrophy; quality of life; questionnaire; sexual function; sexual satisfaction; Taiwan; upper respiratory tract infection; Aged; Drug Administration Schedule; Erectile Dysfunction; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Prostatic Hyperplasia; Quinazolines; Sexual Dysfunction, Physiological; Taiwan; Treatment Outcome
Type
journal article