OXIDATIVE DNA DAMAGE ESTIMATED BY URINARY 8-HYDROXYDEOXYGUANOSINE AND INDOOR AIR POLLUTION AMONG NON- SMOKING OFFICE EMPLOYEES
Resource
ENVIRONMENTAL RESEARCH v.103 n.3 pp.331-337
Journal
ENVIRONMENTAL RESEARCH
Journal Volume
v.103
Journal Issue
n.3
Pages
331-337
Date Issued
2007
Date
2007
Author(s)
LU, CHUNG-YEN
MA, YEE-CHUNG
LIN, JIA-MING
CHUANG, CHUN-YU
SUNG, FUNG-CHANG
Abstract
This study investigated whether urinary 8 - hydroxydeoxyguano sine (8-OHdG), a biomarker of oxidative stress, was associated with indoor air quality for non- smokers in high- rise building offices. With informed consents, urine samples from 344 non-smoking employees in 86 offices were: collected to determine 8-OHdG concentrations. The concentrations of carbon dioxide (CO2) and total volatile organic compounds (TVOCs) in each office and outside of the building were simultaneously measured for eight office hours . The average workday difference between indoor and outdoor CO2 concentrations (dCO(2)) was used as a surrogate measure of the ventilation efficiency for each office unit. The CO2 levels in the offices ranged 467-2810 ppm with a mean of 1170 ppm, or 2.7 times higher than that in the outside air. The average urinary 8-OHdG levels among employees increased from 3. 10 mu g/g creatinine, for those at the lowest tertile levels of both dCO(2) and TVOCs, to 6. 27 mu g/g creatinine, for those at the highest tertile levels. Multivariate logistic regression analysis showed that the risk of having the urinary 8-OHdG level of greater than the median, 4.53 mu g/g creatinine, for participants was increased significantly at the highest tertile dCO(2) level of > 680 ppm (odds ratio (OR) = 3.37, 95% confidence interval (CI) = 1.20-9.46). The effect was significant at the middle tertile TVOCs level of 114-360 ppb (OR = 2.62, 95 % Cl = 1.43-4.79) , but not at the highest tertile. Inadequate ventilation in office increases the risk of building-related oxidative stress in non-smoking employees. (c) 2006 Elsevier Inc. All rights reserved.
Subjects
oxidative stress
8-hydroxydeoxyguanosine
carbon dioxide
volatile organic compounds
ventilation rate
high-rise building office
Type
journal article