Development of Fluorinated Epigallocatechin Gallate Modified Dental Composite Resin
Date Issued
2014
Date
2014
Author(s)
Huang, Szu-Ying
Abstract
The use of dental composite resin material is increasing rapidly in recent years.
This increase is attributed primarily to demand for improved esthetics. Present filling materials are hard to avoid the re-invasion of caries, and the ability of fluoride release
was limited. The role of fluoride in the prevention of caries is well known in dentistry, which is generally thought to help teeth remineralization, inhibit teeth demineralization, antibacterial effects and even anti erosion effects. Otherwise, because of its polymerization shrinkage to cause marginal leakage, and easily for
bacteria adhesion, it still didn’t have the resistant ability to secondary caries. And it limited the success of composite restoration.
The object of this study was to development a novel Fluorinated Epigallocatechin Gallate Modified Dental Composite Resin. Kaolinite (Al2Si2O5(OH)4), a clay mineral, has been known for its ability to carry and absorption of fluoride due to its layered aluminosilicate structure. And
urethane-modified epoxy acrylates was used as resin matrix to form low-shrinking composites, because of their relatively high molecular weight and cohesive energy
density resulting from the presence of the urethane group. We also add epigallocatechin gallate(EGCG) to increase the ability of remineralization.
This study was carried out in three parts：
Part 1: Development of Fluorinated Epigallocatechin Gallate Modified Dental Composite Resin. Including matrix formation, EGCG modification , and synthesis of fluorinited fillers and aluminum oxide fillers.
Part 2 : To assess the fluoride release and recharge, and the physical properties, including the aging effect.
Part 3: An artificial caries model was established for the demineralization and remineralization test. We qualitatively and quantitatively examine the demineralization and remineralization of the restorative teeth sample by the
high-resolution micro computed tomography (Micro-CT) and scanning electron microscope (SEM). We calculate the demineralization volume and average lesion depth with the software to compare the anti-demineralization ability of these materials.
With the results, we can conclude that the Fluorinated Epigallocatechin Gallate Modified Dental Composite Resin has more fluoride release and recharge, lower polymerization shrinkage, and great potential for caries prevention. Because the mechanical properties is not ideal , more studies should be explored.
Subjects
複合樹脂
繼發性齲齒
兒茶素
氟素
高嶺土
人工齲齒模型
去礦化與再礦化
Type
thesis
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