Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1
Journal
Journal of Virology
Journal Volume
79
Journal Issue
21
Pages
13735-13746
Date Issued
2005
Author(s)
Yedavalli V.S.R.K.
Shih H.-M.
Chiang Y.-P.
Chen M.-Y.
Chuang C.-Y.
Dayton A.I.
Jeang K.-T.
Abstract
Human immunodeficiency virus type 1 viral protein R (Vpr) is required for viral pathogenesis and has been implicated in T-cell apoptosis through its activation of caspase 3 and caspase 9 and perturbation of mitochondrial membrane potential. To understand better Vpr-mitochondria interaction, we report here the identification of antiapoptotic mitochondrial protein HAX-1 as a novel Vpr target. We show that Vpr and HAX-1 physically associate with each other. Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr. Copyright ? 2005, American Society for Microbiology. All Rights Reserved.
SDGs
Other Subjects
caspase 3; caspase 9; inhibitor of apoptosis protein; mitochondrial protein; protein HAX 1; unclassified drug; Vpr protein; apoptosis; article; controlled study; enzyme activation; human; human cell; Human immunodeficiency virus 1; membrane potential; mitochondrial membrane; nonhuman; priority journal; protein expression; protein protein interaction; protein targeting; T lymphocyte; virus pathogenesis; Apoptosis; Down-Regulation; Gene Products, vpr; Hela Cells; HIV Infections; HIV-1; Humans; Mitochondria; Protein Binding; Proteins; Human immunodeficiency virus 1
Type
journal article