Association between Plasma Epstein-Barr Virus DNA Level and Female Breast Carcinoma: A Molecular Epidemiological Study
Date Issued
2006
Date
2006
Author(s)
Chen, Chia-Yen
DOI
zh-TW
Abstract
According to the statistics of Taiwan Cancer Registry, female breast cancer has become the second female malignancies in 2001, and its incidence is still rising. Previous studies showed that breast cancer has various risk factors, including hormone-related factors, dietary factors, physical activity, body weight or body mass index, and genetic susceptibility. These traditional risk factors can only be attributable to less than a half of the breast cancer risk in Taiwan. A large proportion of breast cancer risk remains to be elucidated. Therefore, searching for novel risk factors of breast cancer has long been an important issue.
Epstein-Barr virus (EBV) has recently been considered as a possible risk factor of breast cancer. Among 1994 to 2005, there are 20 case series studies showed that the prevalence of EBV in breast tumor tissue ranged from 0 to 66%. These evidences indicated that EBV may play a role in the development of breast cancer. Following these studies, we conducted a cross-sectional case-control study to examine the correlation between plasma EBV DNA level and female breast cancer.
A total of 261 cases and 222 controls were recruited from National Taiwan University Hospital. Exposures to conventional risk factors were obtained through standardized questionnaire interview. Medical charts were abstracted to obtain the clinical and pathological characteristics. Blood samples were collected and tested for EBV DNA level by quantitative polymerase chain reaction. Multiple regression analysis was used to derive odds ratios and their 95% confident intervals (CI) for various risk factors. We found that the female with higher EBV viral load (Ct value≦30.24) has an odds ratio of 2.55 (95% CI = 1.69-3.83), after multiple variable adjustment. By stratified analysis, we found that there was no interaction between EBV viral load and hormone-related risk factors, including early age of menarche, early age of first labor and history of using oral contraceptive. However, the possible synergistic interaction between EBV viral load and genetic susceptibility in breast
cancer needs further investigation to confirm.
Subjects
Epstein-Barr病毒
女性乳癌
定量聚合酶
連鎖反應
病例對照研究
Epstein-Barr virus
female breast cancer
quantitative polymerase chain reaction
case-control study
SDGs
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-95-R93842008-1.pdf
Size
23.31 KB
Format
Adobe PDF
Checksum
(MD5):60a1d16af9b3001590cb2b5aa928a795