Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography
Journal
Medical Image Analysis
Journal Volume
17
Journal Issue
8
Pages
859-876
Date Issued
2013
Author(s)
Kiri?li, H.A.
Schaap, M.
Metz, C.T.
Dharampal, A.S.
Meijboom, W.B.
Papadopoulou, S.L.
Dedic, A.
Nieman, K.
de Graaf, M.A.
Meijs, M.F.L.
Cramer, M.J.
Broersen, A.
Cetin, S.
Eslami, A.
Fl?rez-Valencia, L.
Lor, K.L.
Matuszewski, B.
Melki, I.
Mohr, B.
?ks?z, I.
Shahzad, R.
Wang, C.
Kitslaar, P.H.
Unal, G.
Katouzian, A.
Orkisz, M.
Chen, C.M.
Precioso, F.
Najman, L.
Masood, S.
?nay, D.
van Vliet, L.
Moreno, R.
Goldenberg, R.
Vu?ini, E.
Krestin, G.P.
Niessen, W.J.
Van Walsum, T.
Abstract
Though conventional coronary angiography (CCA) has been the standard of reference for diagnosing coronary artery disease in the past decades, computed tomography angiography (CTA) has rapidly emerged, and is nowadays widely used in clinical practice. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms devised to detect and quantify the coronary artery stenoses, and to segment the coronary artery lumen in CTA data. The objective of this evaluation framework is to demonstrate the feasibility of dedicated algorithms to: (1) (semi-)automatically detect and quantify stenosis on CTA, in comparison with quantitative coronary angiography (QCA) and CTA consensus reading, and (2) (semi-)automatically segment the coronary lumen on CTA, in comparison with expert's manual annotation. A database consisting of 48 multicenter multivendor cardiac CTA datasets with corresponding reference standards are described and made available. The algorithms from 11 research groups were quantitatively evaluated and compared. The results show that (1) some of the current stenosis detection/quantification algorithms may be used for triage or as a second-reader in clinical practice, and that (2) automatic lumen segmentation is possible with a precision similar to that obtained by experts. The framework is open for new submissions through the website, at http://coronary.bigr.nl/stenoses/. ? 2013 Elsevier B.V.
Subjects
Computed tomography angiography (CTA); Coronary arteries; Standardized evaluation framework; Stenoses detection; Stenoses quantification
Other Subjects
Computed tomography angiography; Coronary angiography; Coronary arteries; Coronary artery disease; Coronary artery stenosis; Evaluation framework; Lumen segmentations; Stenoses; Algorithms; Angiocardiography; Image segmentation; Blood vessels; adult; algorithm; article; clinical practice; computer assisted tomography; consensus; controlled study; coronary artery obstruction; data base; diagnostic test accuracy study; emergency health service; feasibility study; female; human; image analysis; male; priority journal; radiodiagnosis; standard; Computed tomography angiography (CTA); Coronary arteries; Standardized evaluation framework; stenoses detection; stenoses quantification; Adult; Aged; Aged, 80 and over; Algorithms; Coronary Angiography; Coronary Stenosis; Humans; Middle Aged; Netherlands; Pattern Recognition, Automated; Radiographic Image Enhancement; Radiographic Image Interpretation, Computer-Assisted; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed
Type
journal article