Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-Based Therapeutic Drug Monitoring
Journal
IEEE Journal of Solid-State Circuits
Journal Volume
55
Journal Issue
11
Pages
2914-2929
Date Issued
2020
Author(s)
簡俊超
Abstract
at a 2.5-kHz filtering bandwidth. We tested our system in human whole blood samples and measured the changes in the ET kinetics from the redox-labeled aptamers at different kanamycin concentrations. By employing principal component analysis (PCA) to compensate for the sampling errors, we report a molecular noise floor (at SNR = 1) of 3.1 µM with sub 1-sec acquisition time at 0.22-mW power consumption.
SDGs
Type
journal article