Monascus purpureus NTU 568 fermented red mold dioscorea improves memory and learning ability in aluminum-induced Alzheimer''s disease rat
Date Issued
2014
Date
2014
Author(s)
Chang, Kuang-Yao
Abstract
Oxidative stress and neuroinflammation induced from accumulation of amyloid β (Aβ) and phosphorylated tau protein (p-tau) are the main causes of Alzheimer’s disease (AD). In this study, aluminum chloride is administered daily to male Sprague-Daw1ey rats via oral gavage to induce AD pathology and degeneration of memory and learning ability. We examined the beneficial effects of Monascus purpureus fermented product (red mold dioscorea, RMD) in this model. First, RMD mitigated cognitive impairment in behavior tests of this study. We then found that RMD restored AD pathology in brain induced by aluminum, including accumulation of Aβ and p-tau, increased amyloid precursor protein (APP) levels, elevated acetylcholinesterase (AChE) activity, and biomarker changed in cerebrospinal fluid (CSF). Furthermore, RMD could reduce oxidative stress and inflammation in rat’s brain. Effects of Aricept, an approved drug for AD, was also examined in this study and showed no significant improvement. Through examining serum biochemical index and tissue of liver and kidney, RMD had no adverse effect on rats in whichever doses. This study shows that by suppressing free radical generation and activating antioxidant enzyme, RMD can reduce oxidative stress and inflammation and then ameliorates AD pathology. Thus, protects rats against aluminum-induced memory and learning ability deficit. In addition, these advantageous effects of RMD on AD are even better than Aricept’s. The protective effect of AD and multifunctional property of RMD makes it a potential candidate in AD treatment and preventive healthcare.
Subjects
阿茲海默症
鋁
大鼠
紅麴山藥
類澱粉樣蛋白
Type
thesis
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