Can diet influence our health by altering intestinal microbiota-derived fecal metabolites?
Journal
mSystems
Journal Volume
3
Journal Issue
2
Pages
e00187-17
Date Issued
2018
Author(s)
Lyu, Q.
Abstract
The human gastrointestinal tract harbors a diverse, highly mutualistic microbial flora which could produce a myriad of specialized metabolites. These specialized metabolites are the chemical cellphones that gut microflora use to communicate with their human host and could potentially be used to cure diseases. Chemical compounds in diet also shape the gut flora. In order to understand which and how the gut microbe-derived specialized metabolites affect human health, the “gut microbiome-metabolomic-human health axis” is thus proposed. In our laboratory, a strategy combining genomic, chemical, phenotypical analyses has been implemented to mine the treasures of bioactive molecules found in our gut and stool. We believe that the cutting edge metabolomics will bridge microbiology and human health. ? 2018 Lyu and Hsu.
Subjects
GNPS; Gut microbiome; Liquid chromatography mass spectrometry; Metabolome
SDGs
Other Subjects
Article; diet; feces microflora; human; intestine flora; nonhuman; priority journal
Type
journal article