Desorption Ionization of Biomolecules on Metals
Resource
Analytical Chemistry 80 (13): 5203-5210
Journal
Analytical Chemistry
Pages
5203-5210
Date Issued
2008
Date
2008
Author(s)
Hsu, Nien-Yeen
Tseng, Susan Yu
Wu, Chung-Yi
Ren, Chien-Tai
Lee, Yuan-Chang
Wong, Chi-Huey
Chen, Chung-Hsuan
Abstract
Direct desorption ionization of various types of biomolecules on metal substrates without the need of matrices was observed by a time-of-flight mass spectrometer. It provides a new convenient method for detection of small biomolecules without the confusion of ion peaks from matrix compounds. Simple commercial Al foil can be used as the substrate to obtain mass spectra of biomolecules without the need of an etching process to produce a porous surface such as with direct ionization on silicon (DIOS). The desorption and ionization mechanism is also discussed.
Type
journal article
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