The diagnosis and classification of autoimmune coagulopathy: An updated review
Journal
Autoimmunity reviews
Journal Volume
13
Journal Issue
4月5日
Pages
587-590
Date Issued
2014
Author(s)
Abstract
Autoantibodies against coagulation factors can develop in patients associated with autoimmune disorders, malignancies, pregnancy, and drug-induced or dermatological diseases. These antibodies can bind to functional epitopes of individual coagulation factors, neutralize their activity or promote their clearance, and clinically leading to bleeding conditions. Among them, the most common one is that directed against factor VIII (FVIII). Patients with autoantibodies against FVIII often have severe hemorrhage and delayed diagnosis can contribute to high mortality in these patients. Further, autoantibodies against other coagulation factors, such as Factors V, XI, XII, XIII, and the vitamin-K dependent proteins, occur more rarely. The pathogenesis for developing autoantibodies against these coagulation factors is still unclear. A mechanism of breakdown in immune tolerance, which may be derived from a combination of genetic and environmental factors as well as the aging of the immune system in elderly individuals, may be responsible for the development of autoantibodies against FVIII. In this article, we reviewed and updated the classification and diagnostic algorithms for identifications of autoantibodies against the coagulation factors in clotting cascade. ? 2014 Elsevier B.V.
SDGs
Other Subjects
activated prothrombin complex; autoantibody; blood clotting factor; blood clotting factor 10; blood clotting factor 11; blood clotting factor 12; blood clotting factor 13; blood clotting factor 5; blood clotting factor 7; blood clotting factor 8; blood clotting factor 8 antibody; blood clotting factor 9; corticosteroid; cyclophosphamide; desmopressin; fibrinogen; immunoglobulin A; immunoglobulin G; immunoglobulin G1; immunoglobulin G4; immunoglobulin M; immunosuppressive agent; prothrombin; rituximab; vitamin K group; aging; autoimmune coagulopathy; autoimmune disease; bleeding; blood clotting disorder; clinical feature; delayed diagnosis; disease classification; environmental factor; hemophilia A; human; immune system; immunoadsorption; immunological tolerance; immunosuppressive treatment; mortality; pathogenesis; plasmapheresis; review; Acquired hemophilia; Acquired inhibitor; Autoantibodies; Autoimmune coagulopathy; Autoantibodies; Autoimmune Diseases; Blood Coagulation Disorders; Blood Coagulation Factors; Humans; Immune Tolerance; Signal Transduction
Publisher
Elsevier
Type
review