The role of cystathionine gama-lyase in prostate cancer metastasis
Date Issued
2016
Date
2016
Author(s)
Huang, Jo-Ting
Abstract
Prostate cancer is one of the most common cancers and the second leading cause of death from cancer in men. Metastatic prostate cancer most commonly spreads to the bones and lymph nodes. Bone metastasis is painful and has no cure. Thus, the main goal of this study is to identify potential drug targets in treating prostate cancer bone metastasis. In this study, the role of a metabolic enzyme, cystathionine gamma-lyase (CTH), was investigated. We found that CTH was up-regulated in bone-metastatic prostate cancer cells, and it positively regulated cell migration, cell invasion and angiogenesis. CTH enhanced expression of IL-1β, resulting in increased phosphorylation of p65 subunit of NF-κB. p65 nuclear translocation was promoted by CTH through H2S and/or IL-1β. Treatment of H2S or IL-1β increased cell invasion and angiogenesis. Collectively, our data suggests that CTH likely plays an important role in promoting prostate cancer cell invasion and metastasis through production of H2S and IL-1β.
Subjects
prostate cancer
cystathionine gamma-lyase
CTH
hydrogen sulfide
interleukin-1 beta
SDGs
Type
thesis
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