Association between genetic risk of melatonin secretion and attention deficit hyperactivity disorder
Journal
Psychiatry Research Communications
Series/Report No.
Psychiatry Research Communications
Journal Volume
4
Journal Issue
3
Start Page
100188
ISSN
2772-5987
Date Issued
2024-09-01
Author(s)
Takahashi, Nagahide
Nishimura, Tomoko
Okumura, Akemi
Harada, Taeko
Iwabuchi, Toshiki
Rahman, Md Shafiur
Liu, Pi-Hua
Nomura, Yoko
Tsuchiya, Kenji J.
DOI
10.1016/j.psycom.2024.100188
Abstract
Sleep problems are common in individuals with ADHD; however, the exact underlying mechanism is unknown. I Data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (N = 27,076), the Taiwan Biobank (N = 2373) and the Hamamatsu Birth Cohort for Mothers and Children (N = 726) were used for analysis. Linkage disequilibrium score-based genetic correlation showed a genetic correlation between melatonin secretion and ADHD diagnosis (rg[SD] = -0.134 [0.012], P < 0.001). Polygenic risk score analyses revealed that genetic variants related to melatonin secretion were associated with ADHD symptoms (beta [SD] = -0.077[0.033], P = 0.019). Dysregulation of melatonin secretion may be associated with the risk of ADHD.
SDGs
Publisher
Elsevier BV
Type
journal article