Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network
Journal
Journal of Cerebral Blood Flow and Metabolism
Journal Volume
36
Journal Issue
4
Pages
665-680
Date Issued
2015
Author(s)
Claassen J.A.
Meel-Van Den Abeelen A.S.
Simpson D.M.
Panerai R.B.
Alexander Caicedo Dorado
Mitsis G.D.
Brassard P.
Ainslie P.N.
Summers P.
Iwasaki K.
Ragauskas A.
Tzeng Y.-C.
M?ller M.
Wang C.-Y.
Hu H.H.
Meel-Van Den Abeelen A.S.S.
Gommer E.
Karemaker J.M.
Aries M.
Van Lieshout J.J.
Semenyuti V.
Aliev V.
Potter J.
Smielewski P.
Liu X.
Czosnyka M.
Payne S.
Bailey D.
Yelicich B.
Puppo C.
Shin D.
Rickards C.A.
Serrador J.
Zhang R.
Marmarelis V.
Novak V.
international Cerebral Autoregulation Research Network (CARNet)
Abstract
Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral perfusion in the presence of blood pressure changes. A large number of methods to assess the quality of cerebral autoregulation have been proposed over the last 30 years. However, no single method has been universally accepted as a gold standard. Therefore, the choice of which method to employ to quantify cerebral autoregulation remains a matter of personal choice. Nevertheless, given the concept that cerebral autoregulation represents the dynamic relationship between blood pressure (stimulus or input) and cerebral blood flow (response or output), transfer function analysis became the most popular approach adopted in studies based on spontaneous fluctuations of blood pressure. Despite its sound theoretical background, the literature shows considerable variation in implementation of transfer function analysis in practice, which has limited comparisons between studies and hindered progress towards clinical application. Therefore, the purpose of the present white paper is to improve standardisation of parameters and settings adopted for application of transfer function analysis in studies of dynamic cerebral autoregulation. The development of these recommendations was initiated by (but not confined to) the Cerebral Autoregulation Research Network (CARNet - www.car-net.org). ? 2016 The Author(s).
Subjects
arterial pressure
autoregulation
brain blood flow
brain injury
brain perfusion
cerebral autoregulation
controlled study
heart cycle
human
mean arterial pressure
middle cerebral artery
priority journal
Review
standardization
animal
blood pressure
brain circulation
homeostasis
meta analysis
neurophysiology
physiology
procedures
Animals
Blood Pressure
Cerebrovascular Circulation
Homeostasis
Humans
Neurophysiology
SDGs
Type
review