Population Attributable Fraction of Diabetes on the Risk of Gastrointestinal Cancers: Overall and by Specific Cancer Sites in a Cohort Study.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Journal Volume
34
Journal Volume
34
Journal Issue
6
Journal Issue
6
Pages
1007 - 1015
Start Page
1007
End Page
1015
ISSN
1538-7755
Date Issued
2025-06-03
Author(s)
Chuang, Shu-Lin
Chu, Teresa Cheng-Chieh
Juan, Yi-Chen
Wang, Ting-Chuan
Yang, Yen-Yun
Wang, Ting-Ann
Chao, Ying-Ting
Lin, Pei-Ju
Yang, Yu-Cih
Wang, Yu-Chun
Abstract
Background: This study aims to assess the population attrib- with 4, 150 of 152, 323 (incidence rate: 3.04 per 1, 000 person-years) utable fraction (PAF) of diabetes on the gastrointestinal cancers patients without diabetes. Diabetes was associated with a higher overall and by specific cancer sites. risk of gastrointestinal cancers (adjusted IRR of 1.24, 95% CI, 1.18-Methods: This study analyzed healthcare data from Taiwan 1.30; PAF: 4.4%, 95% CI, 3.1%-5.8%). The increased risk was (2006-2019) for 2, 362, 587 patients with and without diabetes. primarily driven by pancreatic cancer (adjusted IRR: 1.77, 95% CI, Gastrointestinal cancers were identified via cancer registry data. 1.51-2.09; PAF: 12.9%, 95% CI, 7.9%-18.6%) and colorectal cancer Poisson regression calculated incidence rate ratios (IRR) and 95% (adjusted IRR: 1.28, 95% CI, 1.17-1.39; PAF: 5.1%, 95% CI, 3.0%-confidence intervals (CI), with propensity score-matched pa- 7.5%), with a borderline association for liver cancer (adjusted IRR: tients without diabetes as the reference. PAFs estimated cancer 1.08, 95% CI, 1.00-1.17; PAF: 1.5%, 95% CI, ̵0.3% to 3.5%). incidence attributable to diabetes by sites. Conclusions: Diabetes is associated with an increased risk of Results: 80, 186 patients with diabetes (mean age, 63.3 years; overall gastrointestinal cancers, largely attributable to pancreatic 47.3% women) were matched with 152, 323 patients without and colorectal cancers. diabetes (62.7 years; 48.0% women). By the end of 2021, Impact: Integrating cancer prevention into the objectives of 2, 659 of 80, 186 patients with diabetes (incidence rate: 3.89 per optimal diabetes management is important, especially for cancers 1, 000 person-years) developed gastrointestinal cancers compared with limited screening options. © 2025 American Association for Cancer Research.
SDGs
Type
journal article