長鏈多不飽和脂肪酸對轉錄因子 ADD1和脂肪酸合成之影響機制
Date Issued
2002
Date
2002
Author(s)
DOI
902313B002304
Abstract
Supplementation of dietary fat provides
energy for animals. Fatty acid composition in
many tissues of animals can be modified by
dietary fat sources that have different fatty acid
(FA) composition. Such a modification may
regulate some physiological functions. In pigs,
the FA de novo synthesis and fat accumulation
is primarily located in adipose tissues. The
adipocyte determination and differentiation
factor 1(ADD1) expressed highly in adipose
tissue. It has been shown that polyunsaturated
fatty acid (PUFA) reduced fat deposition in
adipocyte by inhibiting ADD1 expression.
Current research showed that docosahexaenoic
acid (DHA) inhibited ADD1 expression. The
inhibition could be recovered by adding
antioxidant mixture （ 400 nM N,N’-diphenyl-
1,4-diphenylenediamine, 15 M (+)--tocopherol acid
succinate, 600 nM butylated hydroxytoluene, and 160
nM deferoxamine mesylate ） , indicating the
inhibitory effect of DHA to the expression of
ADD1 was partially due to PUFA peroxidation,
however. We could not further prove whether
the inhibition of ADD1 expression by PUFA is
solely via fatty acids peroxidation mechanism.
In conclusion, PUFA inhibit fat deposition in
adipocyte by reducing ADD1 mRNA
expression, but the detail mechanism remains
to be determined.
Subjects
ADD1
FAS
PUFA
Publisher
臺北市：國立臺灣大學動物科學技術學系暨研究所
Type
report
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