Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review
Journal
Taiwanese Journal of Obstetrics and Gynecology
Journal Volume
57
Journal Issue
1
Pages
144-149
Date Issued
2018
Author(s)
Abstract
Objective: To report a case and review published cases of large cell neuroendocrine carcinoma (LCNEC) of the endometrium. Case report: A 51-year-old female presented with postmenopausal bleeding and a palpable pelvic mass. An endometrial biopsy showed a malignant mixed Mullerian tumor (MMMT). Suboptimal debulking surgery was performed. The final pathology revealed stage IVB endometrial LCNEC. Post-operative adjuvant chemotherapy with cisplatin and etoposide was administered. Two months after discontinuing adjuvant chemotherapy, salvage chemotherapy with cisplatin and ifosfamide was administered due to tumor progression; however, obstructive ileus was noted 2 months later. A segmental small bowel resection and palliative colostomy were performed. She died secondary to a post-operative infection 8 days after the operation. Conclusion: Endometrial LCNEC is a rare but aggressive disease. If diagnosed, combined therapies, including staging surgery, following by adjuvant radiotherapy and chemotherapy, should be performed. ? 2018
SDGs
Other Subjects
CA 125 antigen; CD56 antigen; chromogranin; cisplatin; cytokeratin; ertapenem; estrogen receptor; etoposide; ifosfamide; meropenem; mesna; protein p53; synaptophysin; vimentin; antineoplastic agent; cisplatin; etoposide; abdominal discomfort; abdominal infection; abdominal tumor; adjuvant chemotherapy; adult; anorexia; Article; backache; cancer palliative therapy; cancer staging; carcinomatous peritonitis; case report; cause of death; clinical article; clinical evaluation; colostomy; computer assisted tomography; constipation; cytoreductive surgery; drug substitution; drug withdrawal; endometrioid carcinoma; endometrium biopsy; endometrium cancer; endometrium carcinoma; female; follow up; histopathology; human; human tissue; hydroureter; hysterectomy; ileus; immunohistochemistry; laboratory test; laparotomy; large cell neuroendocrine carcinoma; large cell neuroendocrine carcinoma of the endometrium; liver metastasis; lymphadenopathy; medical history; menopausal syndrome; middle aged; mixed Mullerian tumor; multiple organ failure; myometrium; nuclear magnetic resonance imaging; omentectomy; Papanicolaou test; paraaortic lymph node; patient referral; pelvic examination; pelvis tumor; postoperative care; postoperative infection; Pseudomonas; salpingooophorectomy; salvage therapy; small intestine resection; thorax radiography; time to treatment; transvaginal echography; tumor growth; tumor volume; vagina bleeding; carcinoma; endometrium; endometrium tumor; large cell carcinoma; multimodality cancer therapy; pathology; procedures; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Endometrial Neoplasms; Endometrium; Etoposide; Female; Humans; Middle Aged; Salvage Therapy
Type
journal article