SC5005 dissipates the membrane potential to kill Staphylococcus aureus persisters without detectable resistance
Journal
The Journal of antimicrobial chemotherapy
Date Issued
2021-04-14
Author(s)
Lu, Chieh-Hsien
Shiau, Chung-Wai
Lim, Chui-Hian
Yeo, Hui-Hui
Chang, Han-Chu
Chien, Han-Sheng
Huang, Sheng-Hsuan
Hung, Wei-Kang
Wei, Jun-Rong
Abstract
In the past few decades, multiple-antibiotic-resistant Staphylococcus aureus has emerged and quickly spread in hospitals and communities worldwide. Additionally, the formation of antibiotic-tolerant persisters and biofilms further reduces treatment efficacy. Previously, we identified a sorafenib derivative, SC5005, with bactericidal activity against MRSA in vitro and in vivo. Here, we sought to elucidate the resistance status, mode of action and anti-persister activity of this compound.
SDGs
Type
journal article