Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome
Journal
Journal of Oral Pathology and Medicine
Journal Volume
42
Journal Issue
6
Pages
474-479
Date Issued
2013
Author(s)
Abstract
Background: Serum homocysteine level is a biomarker of cardiovascular disease. Methods: In this study, 399 primary and secondary burning mouth syndrome (BMS) patients without or with hematinic deficiencies were treated with vitamin BC capsules plus none, one, or two deficient hematinics depending on the corresponding deficiency statuses of the patients. One hundred and seventy-seven patients showed complete remission of all oral symptoms after treatment. The blood homocysteine, vitamin B12, folic acid, iron, and hemoglobin concentrations at baseline and after treatment till all oral symptoms had disappeared in these 177 complete-response BMS patients were measured and compared by paired t-test. Results: For BMS patients with concomitant deficiencies of vitamin B12 only (n = 48), folic acid only (n = 12), vitamin B12 plus folic acid (n = 9), or vitamin B12 plus iron (n = 15), supplementations with vitamin BC capsules plus corresponding deficient hematinics could significantly reduce the abnormally high serum homocysteine levels to normal levels after a mean treatment period of 5.4-8.2 months (all P-values < 0.01). For BMS patients without definite hematinic deficiencies (n = 62), supplementation with vitamin BC capsules only could also significantly decrease the relatively higher homocysteine levels to significantly lower levels after a mean treatment period of 10.2 months (P < 0.001). Conclusion: Specific supplementations with vitamin BC capsules plus none or corresponding deficient vitamin B12 and/or folic acid can reduce the abnormally high serum homocysteine levels to normal levels in BMS patients without or with deficiencies of corresponding hematinics. ? 2013 John Wiley & Sons A/S.
SDGs
Other Subjects
antianemic agent; cyanocobalamin; folic acid; homocysteine; iron; adult; aged; amino acid blood level; article; burning mouth syndrome; burning sensation; cardiovascular disease; clinical feature; cyanocobalamin deficiency; drug efficacy; female; folic acid deficiency; hemoglobin blood level; hemoglobin determination; human; iron blood level; iron deficiency; major clinical study; male; oral paresthesia; priority journal; Student t test; taste disorder; tongue disease; treatment outcome; treatment response; xerostomia; burning mouth syndrome; folic acid; hemoglobin; homocysteine; iron; vitamin B12; Adult; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Burning Mouth Syndrome; Calcium; Female; Ferric Compounds; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Hematinics; Hemoglobins; Homocysteine; Humans; Iron; Male; Middle Aged; Niacinamide; Pantothenic Acid; Remission Induction; Riboflavin; Thiamine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B Complex
Type
journal article