Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: A case-control study
Journal
Internal Medicine Journal
Journal Volume
35
Journal Issue
3
Pages
188-190
Date Issued
2005
Author(s)
Abstract
The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.
SDGs
Other Subjects
allopurinol; amoxicillin; amoxicillin plus clavulanic acid; ampicillin; carbamazepine; cefadroxil; cefazolin; cefotiam; cephalosporin; chlorzoxazone; lincomycin; meloxicam; methotrexate; nabumetone; naproxen; phenobarbital; phenytoin; salazosulfapyridine; tegafur; tenoxicam; tiaprofenic acid; article; calculation; case control study; disease association; drug safety; experience; high risk population; hospital discharge; human; multivariate analysis; priority journal; risk assessment; side effect; Stevens Johnson syndrome; toxic epidermal necrolysis; Adult; Allopurinol; Analgesics, Non-Narcotic; Anticonvulsants; Antimetabolites; Carbamazepine; Case-Control Studies; Drug Therapy; Epidermal Necrolysis, Toxic; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Phenytoin; Risk Assessment; Stevens-Johnson Syndrome; Taiwan
Type
journal article