Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
Journal
Scientific Reports
Journal Volume
10
Journal Issue
1
Pages
16772
Date Issued
2020
Author(s)
Pai, Chen-Hsueh
Lin, Shu-Rung
Liu, Chia-Hao
Hsu, Hao
Yen, Ching-Tzu
Yu, I-Shing
Wu, Hua-Lin
Abstract
mice. Because galectin-3-deficient macrophages showed decreased Ccl17 and Ccl22 in fibrotic kidneys, we further demonstrated that CD248 interacted specifically with galectin-3 of macrophages who then expressed CCL17 to activate collagen production in myofibroblasts. Mice with DNA vaccination targeting CD248 showed decreased fibrosis. We thus propose that CD248 targeting should be studied in the clinical tissue fibrosis setting.
SDGs
Other Subjects
Ccl17 protein, mouse; CD248 protein, mouse; leukocyte antigen; thymus and activation regulated chemokine; tumor antigen; animal; fibroblast; fibrosis; genetics; kidney disease; knockout mouse; macrophage; metabolism; mouse; myofibroblast; pathology; peritoneal fibrosis; Animals; Antigens, CD; Antigens, Neoplasm; Chemokine CCL17; Fibroblasts; Fibrosis; Kidney Diseases; Macrophages; Mice; Mice, Knockout; Myofibroblasts; Peritoneal Fibrosis
Publisher
Nature Research
Type
journal article