行政院國家科學委員會補助專題研究計畫成果報告:發展整合型的母幼鼠急性反應測試方法來檢測多氯聯苯之毒性(1/3)
Date Issued
2000
Date
2000
Author(s)
DOI
892320B002024
Abstract
Recently, there is increasing public and
scientific concern that some environmental
pollutants may cause hormone disruption in
human and wildlife. Therefore, there is an
urgent need to develop an effective assay
which can detect environmental hormone. In
this study, an integrated bioassay which
using acute responses of prepubertal female
rats will be expanded and developed to
examine effects of PCB 132 (2,2’,3,3’,4,6’-
hexachlorobiphenyl) and PCB 149
(2,2’,3,4’5’6-hexachlorobiphenyl) on
estrogenicity, hepatic enzyme activities,
thyroxine, and brain dopamine as well as
norepinephrine levels. First year of this
project, it was focused to standardize the
methods of the uterotropic responses as well
as hepatic enzyme activities. The result of
this study showed that PCB 132 and PCB
149 did not produce any uterotropic
responses in prepubertal female rats at 8
mg/kg, 32 mg/kg and 96 mg/kg. PCB 132
and PCB 149 did not increase liver
microsomal P450 1A enzyme activities of
prepubertal female rats. However, there was
an increase P450 2B activity at prepubertal
female rats administered PCB 149 at 96
mg/kg. It indicated that PCB 149 was a PBtype
enzyme inducer. The toxic effects of
2,3,6-substitiued PCB congeners were nondioxin-
like.
Subjects
Polychlorinated biphenyl
Estrogenic effects
Hepatic enzymes
Prepubertal female rats
Acute
Response bioassay
Response bioassay
SDGs
Publisher
臺北市：國立臺灣大學地理環境資源學系暨研究所
Type
report
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