Type I IL-1 receptor (IL-1RI) as potential new therapeutic target for bronchial asthma
Journal
Mediators of Inflammation
Journal Volume
2010
Pages
567351
Date Issued
2010
Abstract
The IL-1R/TLR family has been receiving considerable attention as potential regulators of inflammation through their ability to act as either activators or suppressors of inflammation. Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, allergic inflammation, elevated serum total, allergen-specific IgE levels, and increased Th2 cytokine production. The discovery that the IL-1RIIL-1 and ST2IL-33 pathways are crucial for allergic inflammation has raised interest in these receptors as potential targets for developing new therapeutic strategies for bronchial asthma. This paper discusses the current use of neutralizing mAb or soluble receptor constructs to deplete cytokines, the use of neutralizing mAb or recombinant receptor antagonists to block cytokine receptors, and gene therapy from experimental studies in asthma. Targeting IL-1RIIL-1 as well as ST2IL-33 pathways may promise a disease-modifying approach in the future. Copyright ? 2010 Jyh-Hong Lee et al.
SDGs
Other Subjects
cytokine receptor; Drosophila protein; heterodimer; immunoglobulin A; immunoglobulin E; immunoglobulin enhancer binding protein; immunoglobulin G; interleukin 1 receptor; interleukin 1 receptor associated kinase; interleukin 1 receptor blocking agent; interleukin 13; interleukin 1alpha; interleukin 1beta; interleukin 33; interleukin 4; interleukin 5; messenger RNA; mitogen activated protein kinase; myeloid differentiation factor 88; neutralizing antibody; ovalbumin; recombinant interleukin 1 receptor blocking agent; recombinant receptor; transcription factor AP 1; tumor necrosis factor receptor associated factor; interleukin 1 receptor; isoprotein; neutralizing antibody; allergic asthma; allergic reaction; antibody response; asthma; cytokine production; eosinophil; gene therapy; gene transfer; granulocyte; human; immune response; immune system; inflammation; lung granuloma; lymphocyte; nonhuman; priority journal; review; signal transduction; smooth muscle fiber; Th2 cell; animal; asthma; drug antagonism; genetics; immunology; Animals; Antibodies, Neutralizing; Asthma; Humans; Protein Isoforms; Receptors, Interleukin-1; Signal Transduction
Type
review