Cytotoxic protobassic acid glycosides from Planchonella obovata leaf
Journal
Phytochemistry Letters
Journal Volume
11
Pages
229-235
Date Issued
2015
Author(s)
Abstract
Four triterpenoid glycosides, possessing protobassic acid as common aglycon, together with 16 known compounds were isolated from the leaves of Planchonella obovata. They are 6β-hydroxy-conyzasaponin G (2), 3⌄-O-de-β-D-apiofuranosylisoarganin F (3), isoarganin F (4), and 6β-hydroxy-conyzasaponin N (5). The structures of these glycosides were elucidated based on spectroscopic analysis, in particular using 1D TOCSY to con.rm the 1H NMR assignment of each sugar residue. The absolute con.guration of each monosaccharide in the glycon part was determined by GC-FID. Compound 5, Mi-saponin A (8), and ursolic acid (10) showed moderate inhibitory activities against HL-60 leukemia cell line with the IC50 values of 16.88, 15.50, and 12.68 μM, respectively.
Type
journal article