Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese
Journal
Journal of Neural Transmission
Journal Volume
109
Journal Issue
11
Pages
1403-1414
Date Issued
2002
Author(s)
Abstract
Cytochrome P450IIE1 (CYP2E1), an ethanol-inducible cytochrome P450 enzyme, is expressed in the basal ganglia and is probably involved in the activation of neurotoxicants, producing free radical metabolites and resulting in oxidative stress. To examine the association between CYP2E1 polymorphism and the risk of Parkinson's disease (PD), we performed a case-control study on a large population of Taiwanese PD patients, focusing especially on early-onset PD patients (onset at, or before, the age of 50). Two hundred and thirty-four PD patients and 251 age- and sex-matched controls were recruited. A much higher frequency of the uncommon c2 allele was seen in our control subjects than in Caucasians (0.23 vs. 0.02). There were no significant differences between PD patients and controls in the distribution of either allelic or genotype frequencies. Our results suggest that CYP2E1 is not a major or independent determinant in the occurrence of PD in Taiwanese.
SDGs
Other Subjects
cytochrome P450 2E1; neurotoxin; cytochrome P450 2E1; adult; aged; article; basal ganglion; case control study; Caucasian; controlled study; disease predisposition; female; gene frequency; genetic polymorphism; genotype; human; major clinical study; male; onset age; oxidative stress; Parkinson disease; priority journal; protein expression; Taiwan; allele; genetic predisposition; genetics; middle aged; Parkinson disease; Taiwan; Age of Onset; Aged; Alleles; Case-Control Studies; Cytochrome P-450 CYP2E1; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Taiwan
Type
journal article