The role of continuous in situ targeted antimicrobials in the successful treatment of extensively-drug resistant left ventricular assist device driveline infection - A case report.
Journal
JHLT open
Journal Volume
13
Start Page
Article number 100570
ISSN
2950-1334
Date Issued
2026-08
Author(s)
Lin, Wei-Ting
Fan, Chiung-Ta
Huang, Chieh-Huei
Chen, Yih-Sharng
Hsu, Ron-Bin
Yu, Hsi-Yu
Abstract
Left ventricular assist device (LVAD) driveline infections (DLIs) are common complications (1) and frequently recur despite definite treatment due to bacterial entry and biofilm formation. We report the first case of recurrent, extensively drug-resistant LVAD infection successfully cured using systemic antimicrobials, continuous in-situ targeted antibiotics (CITA), and repeated surgical interventions, highlighting CITA's therapeutic potential.
Subjects
Continuous-In-Situ Targeted Antimicrobials
Driveline infection
XDR-Pseudomonas aeruginosa
Type
journal article