Association of human papillomavirus with oral buccal mucosa premalignant lesions
Date Issued
2008
Date
2008
Author(s)
Chen, Wei-Chuan
Abstract
Backgrounduccal squamous cell carcinoma (SCC) is the most common oral malignant tumor in Taiwan. Betel quid (BQ) chewing is the most important risk factor for the buccal mucosal carcinogenesis. Previous studies showed that human papillomaviruses (HPVs), particularly high-risk HPVs, play an important role in the development of oral SCCs (OSCCs), especially the non-oral habits (OH)-associated OSCCs. aterials and methods o evaluate the etiologic role of HPVs in buccal mucosal carcinogenesis, DNA samples were purified from 100 buccal premalignant lesions, including 30 hyperkeratosis, 25 verrucous hyperplasia, 15 mild dysplasia, 16 moderate dysplasia, and 14 severe dysplasia lesions, and 30 normal oral mucosa (NOM) specimens. A nested-polymerase chain reaction, DNA sequencing, and gene-chip HPV typing was used to detect 39 subtypes of HPV DNA in our samples. The HPV prevalence rates in different buccal premalignant groups and their correlation with clinicopathological parameters of patients with buccal premalignant lesions were analyzed by chi-square test. esults here was no significant difference in the overall HPV-positive rate between buccal premalignant lesion samples (21%) and NOM samples (20%). The overall HPV-positive rate was higher in non-OH-associated premalignant lesion samples (30%, 8/27) than in OH-associated premalignant lesion samples (18%, 13/73), although the difference was not significant. The HPV positivity was significantly associated with histological type of disease (P = 0.012) and disease progression (P = 0.078, marginal significance). HPV infection occurred more frequently in oral verrucous hyperplasia and severe dysplasia lesions than in other premalignant lesions. Moreover, the malignant transformation rate was higher in HPV-positive premalignant lesions (62%, 13/21) than in HPV-negative premalignant lesions (39%, 31/79). The malignant transformation rate was 78% (7/9) for premalignant lesions with high-risk HPV infection, 33% (3/9) for those with low-risk HPV infection, and 100% (3/3) for those with multiple HPV infections. Premalignant lesions with high-risk or multiple HPV infections had greater potential to become a more advanced premalignant lesion or a malignancy (P = 0.044). onclusionsigh-risk and multiple HPV infections may play an important role in the transformation of a buccal premalignant lesion, especially a non-OH-associated buccal premalignant lesion, into an oral SCC.
Subjects
human papillomavirus
premalignant lesions
SDGs
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