Enantioseparation of Catecholamines and Structurally Related Compounds by Capillary Zone Electrophoresis Using Sulfated-β-Cyclodextrin as Chiral Selectors.
Date Issued
2004
Date
2004
Author(s)
Cheng, Hsu-Tun
DOI
zh-TW
Abstract
In this study, we focus on the enantioseparation of three catecholamines and three structurally related compounds with addition of sulfated cyclodextrins and the optimization of separation. The influences of buffer concentration and temperature on the migration behavior and enantioseparation of these cationic solutes with addition of sulfated cyclodextrins were investigated. The results indicate that, buffer concentration and temperature play important roles in the enantioseparation of these cationic solutes. In order to understand enantoseparation mechanisms of these cationic solutes also used three kind of neutral cyclodextrins as chiral selectors. Moreover, by mixing two kind of cyclodextrins, we found the reversal of migration order of norephedrine、synephrine and octopamine. The interaction of chiral analytes with chiral selectors was studied through the variation of mobility of norephedrine、synephrine and octopamine.
Subjects
兒茶酚
胺對掌異構物
對掌分離
環糊精
Catecholamine
chiral separation
cyclodextrin
enant
Type
thesis
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