Receptor protein complexes are in control of autophagy
Journal
Autophagy
Journal Volume
8
Journal Issue
11
Pages
1701-1705
Date Issued
2012
Author(s)
Mijaljica, D.
Abstract
In autophagic processes a variety of cargos is delivered to the degradative compartment of cells. Recent progress in autophagy research has provided support for the notion that when autophagic processes are operating in selective mode, a receptor protein complex will process the cargo. Here we present a concept of receptor protein complexes as comprising a functional tetrad of components: a ligand, a receptor, a scaffold and an Atg8 family protein. Our current understanding of each of the four components and their interaction in the context of cargo selection are considered in turn.
Type
journal article