Ecological risk evaluation of titanium dioxide nanoparticles in Caneorhabdities elegans
Date Issued
2014
Date
2014
Author(s)
Yen, Hsin
Abstract
Nanoparticles (NPs) have been considered as potential emerging contaminants in the environment. Titanium dioxide nanoparticles (TiO2-NPs) are one of the most used NPs in the world. TiO2-NPs caused toxic effect on the nervous system and the reproductive system of the organisms. In addition TiO2-NPs might induce possible carcinogenesis. Thus, TiO2-NPs might induce potential risks to human health and other organisms. Several studies have demonstrated that TiO2-NPs caused lethality to the environment organisms. However, for the potential risk of sub-lethal effect of TiO2-NPs have not assessed. In the present study, Caenorhabditis elegans (C. elegans) was used as risk assessment model organism to assess the potential neurotoxic risk and population risk upon TiO2-NPs exposure. The results showed that smaller size of TiO2-NPs (4 nm) exposure resulted in higher neurotoxic and oxidative stress risk. Moreover, the results showed that TiO2-NPs exposure caused C. elegans mortality, growth inhibition and reproduction decline. By fitting the toxicological data, modeling result showed that population growth rates of C. elegans were decreased as the concentration of TiO2-NPsincrease. In addition, when C. elegans populations were exposed of TiO2-NPs, the progeny population exhibited high risk of population decline. Results from this study can provide valuable information for environmental risk assessment.
Subjects
奈米二氧化鈦
秀麗隱桿線蟲
環境神經毒風險
族群風險
SDGs
Type
thesis
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