The Study on the Glucose Transport, Glucose Transporter Expression and the Affection of Serum Factor on Polymorphonuclear Neutrophils of Patients with Systemic Lupus Erythematosus
Date Issued
2004
Date
2004
Author(s)
Wu, Chien-Sheng
DOI
zh-TW
Abstract
Objective：
The study intended to examine glucose transport and the expression of glucose transporter (GLUT) 1, 3, 6 on normal and systemic lupus erythematosus (SLE) polymorphonuclear neutrophil (PMN) and SLE serum effects on normal PMN that has not reported in the literature.
Method:
PMN and serum were obtained from normal volunteers (n=12, mean age 32, F:M = 4:8) and SLE patients (n=29, mean age 37, F:M =24:5). Patients should fulfill The American College of Rheumatology 1997 revised classification criteria for SLE. Infection should be ruled out. Experimental designs included (1) GLUT1, GLUT3, GLUT6 expression on normal and SLE PMN. (2) The effect of LPS (100 ng/ml),IL-8 (25 ng/ml) and TNF-
Subjects
全身性紅斑狼瘡
多形核嗜中性白血球
葡萄糖傳送
乳酸濃度
葡萄糖螢光類同物
葡萄糖傳送分子
SLE
PMN
glucose fluorescence analogue
lactate concentration
glucose transporter
glucose transport
Type
other
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