空氣污染引發之易感受族群急性健康效應之短期世代研究(2/2)
Other Title
Panel Study on Air Pollution-Induced Acute Health Effects
among Susceptible Population(2/2)
among Susceptible Population(2/2)
Date Issued
2002-07-31
Date
2002-07-31
Author(s)
DOI
902320B002126
Abstract
The potential for preexistent disease
such as cardiopulmonary disease to alter
adverse induced by air pollutants is widely
acknowledged. Recently several
epidemiological studies have reported the
link between particulate air pollution and
acute health effects, morbidity and mortality
associated with cardiopulmonary disease.
We conducted a panel study on 10
susceptible adults and elders with either
chronic obstructive pulmonary diseases
(COPD) or obstructive sleep apnea
syndromes (OSAS). in order to evaluate
whether air pollution exposures will affect
physiologic parameters. We measured
continuously each subject’s 24-hour air
pollutants personal exposure such as ultrafine
particle (PM1, particulates ≦1 ìm in
diameter), carbon monoxide and physiologic
parameters such as heart rate, heart rate
variability and blood pressure. We used
linear mixed-effects models to estimate the
relationship between particle exposures and
their physiological response
After adjusting for age, body mass
index, tobacco exposure and disease. We
found significant association between particle
exposures and blood pressure, HRV
parameters. The decrease in HRV became
larger as the exposure metric increased.
Our findings suggested that ultrafine
particles might have short-term effects and
long-term effects on susceptible population’s
of HRV as well as blood pressures in wake and sleep periods. The mechanism of effects
that may be relate to the autonomic stress
response or the production of cytokines. We
consider OSAS adult and COPD elderly are
susceptible population.
Subjects
ultrafine particle
heart rate
variability
variability
blood pressure
susceptible population
epidemiology
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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