以 FTY720 治療器官移植之慢性排斥－大白鼠動物模型
Date Issued
1999
Date
1999
Author(s)
闕士傑
DOI
882314B002190
Abstract
This study elucidated the role of FTY720, a novel immunosuppressant, in
prevention of chronic rejection by using a well-established animal model (Lewis to Fisher 344
heterotopic cardiac transplant) of chronic rejection. The rats treated by minimal doses (0.25-
0.5 mg/kg/day x 7 days) of FTY720 prolonged the mean survival time (MST) to 46-58 days,
which were modestly but significantly longer than that of the control group (without any
treatment, MST= 21.7+/-9.6 days, both P < 0.05). Increased dosage of FTY720 (1-2 mg/kg/d
x 7 days) dramatically and significantly extended the MSTs to more than 100 days (both
groups, P< 0.01). Pathologic examinations of the cardiac allografts showed alleviation in the
severity of vascular changes of chronic rejections in the groups treated with 1-2 mg/kg/d x 7
days of FTY720. In conclusion, FTY720 might play an important role in long term acceptance
of rat cardiac allografts. Its clinical application may help to prevent chronic rejection.
Subjects
organ transplantation, chronic rejection, FTY720
Publisher
臺北市：國立臺灣大學醫學院泌尿科
Type
other
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