行政院國家科學委員會補助專題研究計畫成果報告:抗氧化物 Silymarin 對免疫細胞的作用
Date Issued
2002
Date
2002
Author(s)
林大盛
DOI
902320B002118
Abstract
Silymarin, the active extract of milk
thistle (Silybum marianum), has been used
for the treatment of liver diseases for
centuries. It is evident that biological
activities of silymarin are similar to vitamin
E being membrane-active antioxidant.
Silymarin can protect cell membrane damage
done by H2O2 and other free radicals and also
can enhance the superoxide dismutase
activity of lymphocytes and erythrocytes.
Therefore, it is believed that antioxidant
activity is an important ability of silymarin
for liver protection. In addition, some
studies indicate that silymarin can influence
lymphocyte activation and enhance
lectin-induced lymphoblast transformations.
Thus, it is suggested that silymarin may also
offer liver protection ability by influencing
immune cell responses. Although the
efficiency of silymarin for the therapy of liver
diseases still needs verification by further
human clinical trials, as described above
silymarin has already been used widely for
the therapy of human and animal liver
diseases. Therefore, it is necessary to
understand the effects of silymain on immune
system in the body. Because biological
activities of silymarin are similar to vitamin
E, which has been proved to be an
immunomodulator, the purpose of this study
will investigate if silymarin also an
immunomodulator as well. The following
items will be examined for the effects of
silymarin on immunity: IL-1 secretion and
tumorcidal activity of macrophages,
stimulation of lymphocyte proliferation, and
influence of Th1/Th2 type immune
responses.
It was found that silymarin could
directly stimulate lymphocyte proliferation.
This effect would be significantly enhanced
when PHA was also present. At the same
time, silymarin promoted both Th1 and Th2
responses. However, the former was
enhanced greater than the latter. Silymarin
plus LPS could enhance both IL-1 secretion
and tumorcidal activity of macrophages.
Subjects
immunomodulation
cell-mediated immunity
Th1-/Th2-type cytokines
SDGs
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
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