Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion
Journal
Journal of Colloid and Interface Science
Journal Volume
530
Start Page
473
End Page
480
ISSN
0021-9797
Date Issued
2018-11
Author(s)
Abstract
In order to achieve the highly efficient 99mTc production from 100MoO3 by the 100Mo(n, 2n)99Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.
Subjects
Lipid bilayer
Nanoparticle
Phosphatidyl choline
Sublimation method
Tc generator
SDGs
Publisher
Elsevier BV
Type
journal article