Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan
Journal
Journal of Infectious Diseases
Journal Volume
193
Journal Issue
2
Pages
283-286
Date Issued
2006
Author(s)
Berkhout B.
Yang H.-C.
Abstract
We investigated whether infection with a novel human coronavirus (HCoV), called "New Haven coronavirus" (HCoV-NH)-which is similar to and likely represents the same species as another novel HCoV, HCoV-NL63-is associated with Kawasaki disease (KD) in Taiwan. Fifty-three patients with KD were enrolled in our study. Serum, peripheral-blood mononuclear cells, nasopharyngeal aspirates, throat swabs, and rectal swabs from these patients were assayed for HCoV-NL63 by real-time reverse-transcriptase (RT) polymerase chain reaction (PCR), and the throat swabs, nasopharyngeal aspirates, and rectal swabs were also assayed for HCoV-NH by RT-PCR. All PCR results were negative for both HCoV-NL63 and HCoV-NH; therefore, we did not find any association between HCoV-NH infection and KD in Taiwan. ? 2005 by the Infectious Diseases Society of America. All rights reserved.
Other Subjects
article; Coronavirus; Coronavirus nl63; disease association; female; human; major clinical study; male; mononuclear cell; mucocutaneous lymph node syndrome; nasopharynx; nucleotide sequence; preschool child; priority journal; real time polymerase chain reaction; rectum; reverse transcription polymerase chain reaction; Taiwan; throat culture; virus infection; virus strain
Type
journal article