Eicosapentaenoic acid protects cardiomyoblasts from lipotoxicity in an autophagy-dependent manner
Journal
Cell biology and toxicology
Journal Volume
34
Journal Issue
3
Pages
177
Date Issued
2018
Author(s)
Abstract
The cardiovascular health benefits of eicosapentaenoic acid (EPA) have been demonstrated previously; however, the exact mechanism underlying them remains unclear. Our previous study found that lipotoxicity induced cardiomyocyte apoptosis via the inhibition of autophagy. Accordingly, in this study, we investigated whether EPA attenuated lipotoxicity-induced cardiomyocyte apoptosis through autophagy regulation. The role of EPA in mitochondrial dynamics was analyzed as well.
Subjects
Autophagy; Eicosapentaenoic acid; In vitro model; Lipotoxicity; Mitochondrial dynamics; Palmitic acid
SDGs
Publisher
SPRINGER
Type
journal article