Prostate Health Index Density Outperforms Prostate Health Index in Clinically Significant Prostate Cancer Detection
Journal
Frontiers in oncology
Journal Volume
11
Date Issued
2021-11
Author(s)
Cheng, Yung-Ting
Chung, Shiu-Dong
Chiang, Chih-Hung
Abstract
Prostate-specific antigen (PSA) is considered neither sensitive nor specific for prostate cancer (PCa). We aimed to compare total PSA (tPSA), percentage of free PSA (%fPSA), the PSA density (PSAD), Prostate Health Index (PHI), and the PHI density (PHID) to see which one could best predict clinically significant prostate cancer (csPCa): a potentially lethal disease.
Subjects
clinically significant prostate cancer; predict lethal disease; prostate health index density; risk table; save unnecessary prostate biopsy
SDGs
Other Subjects
biological marker; prostate specific antigen; adult; area under the curve; Article; blood sampling; cancer diagnosis; cancer grading; cancer risk; cancer screening; chemiluminescence immunoassay; clinical assessment; clinical practice; comparative study; controlled study; diagnostic accuracy; diagnostic test accuracy study; digital rectal examination; Gleason score; human; human tissue; major clinical study; male; prospective study; prostate biopsy; prostate cancer; Prostate Health Index; Prostate Health Index density; prostate volume; prostatectomy; receiver operating characteristic; sensitivity and specificity; transrectal ultrasonography; transrectal ultrasound guided biopsy; transurethral resection
Publisher
FRONTIERS MEDIA SA
Type
journal article