Micronization of Pharmaceutical Compounds Using Batch Gas Anti-Solvent Precipitation
Date Issued
2004
Date
2004
Author(s)
Yu, Yi-Huei
DOI
zh-TW
Abstract
Micronization of seven pharmaceutical compounds, carbamazepine, carisoprodol, gallic acid, nitrofurantoin, salicylsalicylic acid, sulindac and terfenadine by using batch gas antisolvent precipitation (GAS) was investigated in this research. SEM showed the micronization of particles
Sulindac was investigated for the effect of some key process parameters. Carbon dioxide was used as an antisolvent. Methanol, ethanol and acetone were used as solvents. Particle morphology was determined by SEM which showed the particles had irregular shapes after the GAS process. Crystal structure analyzed by XRD showed different crystal habits after the GAS process. Further investigation by DSC demonstrated no phase transition and decomposition on sulindac. Process parameters, such as solvent used, solution amount, pressurized type, final pressure, temperature and solution concentration were investigated. The micronized sulindac with sizes of 1μm was obtained from 3mL acetone solution which was 90% of saturation at 298K after rapid pressurized up to 120 bar.
Subjects
藥物微粒化
氣體反溶劑法
超臨界
GAS
antisolvent
supercritical
micronization
Type
thesis
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