Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Journal Volume
28
Journal Issue
3
Date Issued
2012-03
Author(s)
Chang, Charn-Jung
Chiang, Chih-Hung
Song, Wen-Shin
Tsai, Shen-Kou
Chang, Chin-Hong
Jeng, Shaw-Yeu
Tsai, Ching-Yao
Hsu, Chuan-Chih
Lee, Hung-Fu
Huang, Chi-Shuan
Yung, Ming-Chi
Liu, Jorn-Hon
Lu, Kai-Hsi
Abstract
CD133 (PROM1) is a potential marker for cancer stem cells (CSCs), including those found in brain tumors. Recently, medulloblastoma (MB)-derived CD133-positive cells were found to have CSC-like properties and were proposed to be important contributors to tumorigenicity, cancer progression, and chemoradioresistance. However, the biomolecular pathways and therapeutic targets specific to MB-derived CSCs remain unresolved.
Subjects
Cancer stem cells | CD133 | Cucurbitacin I | Medulloblastoma | Radioresistance | STAT3
SDGs
Type
journal article